|Keywords Biological systems analysis, Medical applications, Biological systems control
Robustness is a ubiquitously observed property of biological systems. It is considered to be a fundamental feature of complex evolvable systems. The author wish to formulate a basic framework in which various biological properties as well as medical issues can be described and understood in a consistent manner, as the theory of biological robustness . It is expected to be one of the underlying thrust of systems biology , . It is attained by several underlying principles that are universal to both biological organisms and sophisticated engineering systems. Robustness facilitates evolvability and robust traits are often selected by evolution. Such a mutually beneficial process is made possible by specific architectural features observed in robust systems. But there are trade-offs between robustness, fragility, performance and resource demands, which explain system behaviour, including the patterns of failure. Insights into inherent properties of robust systems will provide us with a better understanding of complex diseases, such as cancer , , diabetes , and autoimmune disorders, and a guiding principle for therapy design.
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